You might be eligible for a Genius discount at Twentyone Hotel. To check if a Genius discount is available for your selected dates sign in.

Genius discounts at this property are subject to book dates, stay dates and other available deals.

About this property

The Twentyone is a modern boutique hotel on Via Cola di Rienzo, one of Rome's best shopping streets. Castel Sant'Angelo and the historic centre are just a pleasant 10-minute walk away. Rooms at the Twentyone Hotel are ultra modern and feature a minimalist décor. They offer an LCD satellite TV, air conditioning, minibar, and free WiFi. In the breakfast room located on the roof, where you can enjoy the city view, a breakfast buffet awaits you every morning. Open for lunch and dinner, the on-site restaurant serves traditional Roman and classic Italian dishes and a large selection of wines and champagne. Inside the hotel there is a Starbucks which Guests can access directly and where they can have breakfast. The hotel is in the elegant Prati district, home to the Vatican and Saint Peter's Basilica, which are a 15-minute walk away. Lepanto Metro Station is 450 metres from the property, while bus links to Roma Termini Train Station are located close by.

Couples particularly like the location — they rated it 9.2 for a two-person trip.

Distance in property description is calculated using © OpenStreetMap

Property highlights

Perfect for a 3-night stay!

  • Situated in the real heart of Rome, this hotel has an excellent location score of 9.2

  • Top pick by families with children

Breakfast info

Continental, American

Private parking at the hotel


Sign in, save money

To see if you can save 10% or more at this property, sign in
Sign in, save money
 ! 

Please select one or more options you want to book

Availability

Prices converted to USD
We have no availability on our site for this property between Sun 21 Sept 2025 and Wed 24 Sept 2025

Select different dates to see more availability

Checking for other dates
Room type
Number of guests
Price
1 large double bed
Not available on our site for your dates
1 large double bed
Not available on our site for your dates
3 single beds
Not available on our site for your dates
1 extra-large double bed
Not available on our site for your dates
1 large double bed
Not available on our site for your dates
2 single beds
Not available on our site for your dates
2 single beds
Not available on our site for your dates
Something went wrong. Please try again later.
Something went wrong. Please try again later.
Something went wrong. Please try again later.
Something went wrong. Please try again later.
Something went wrong. Please try again later.
Something went wrong. Please try again later.
Something went wrong. Please try again later.
Limited supply in Rome for your dates: 17 four-star hotels like this are already unavailable on our site

Guest reviews

Categories:

Staff
Facilities
Cleanliness
Comfort
Value for money
Location
Free WiFi

Select topics to read reviews:

Guests who stayed here loved

  • Hoare
    Ireland Ireland
    The location is very good, quiet street at night. Very clean, room cleaned everyday and fresh towels. Good air conditioning. Staff are nice and we received some refreshments in the morning for our early flight.
  • Maureen
    Ireland Ireland
    The location was great, 20 min walk from the Vatican. A longer walk to Colloseum. However, there are buses if you dont want a longer walk. It was away from the main tourist areas, so it was quiet at night, but still close enough to enjoy them....
  • Justin
    United Kingdom United Kingdom
    Comfortable room with lovely balcony. Restaurant and rooftop bar.
  • Chris
    United Kingdom United Kingdom
    Reception were very helpful. We did not book parking and although the hotel was very busy the kind reception was very accommodating
  • Alexandra
    Greece Greece
    Very good hotel! Great location in beautiful neighbourhood. Walking distance from the city Center. Excellent cleaning service. The room was cleaned every day. The staff were friendly and helpful. Many choices for breakfast. I strongly recommend it.
  • Bernhard
    Switzerland Switzerland
    Situated in the Prato quarter, lots of shops and restaurants are located in the surroundings. Staff super friendly, breakfast with a wide variety and fresh coffee. Rooms clean and nit too tiny. Vaticano a 15 mins walk. Strongly recommended for a...
  • Joanne
    Canada Canada
    The room was clean and well maintained. I appreciate the daily service and room cleaning as well as the included breakfast. The staff were always friendly, helpful and very accommodating.
  • Mary
    Malaysia Malaysia
    Good location in a peaceful neighbourhood with lots of cafes and restaurants. Good vibe .
  • David
    Ireland Ireland
    This was a nice stay overall in a well located hotel. -Staff friendly and were very obliging. -Location amazing and 15 mins walk to Vatican -Breakfast was nice with lovely panorama of city. -Bed was fine. -Towels...
  • Tim
    United Kingdom United Kingdom
    The hotel is in a nice bussling part of Rome 15 minutes for the Vatican and about 25 minutes from the Trevi Fountian. You get to see some great sights walking in either direction. Hotel staff were exceptionally helpful and polite, and the rooms...

Hotel surroundings

Restaurants

1 restaurant on site
  • Vista
    • Cuisine
      International
    • Ambiance
      Modern
    • Dietary options
      Vegetarian

House rules

Twentyone Hotel takes special requests - add in the next step!
Check-in
From 15:00 to 00:00
Check-out
From 07:00 to 11:00
Cancellation/ prepayment
Cancellation and prepayment policies vary according to accommodation type. Please check what conditions may apply to each option when making your selection.
Children and beds

Child policies

Children of any age are welcome.

To see correct prices and occupancy information, please add the number of children in your group and their ages to your search.

Cot and extra bed policies

The number of cots allowed is dependent on the option you choose. Please check your selected option for more information.

There are no extra beds available at this property.

All cots are subject to availability.

No age restriction
There is no age requirement for check-in
Pets
Pets are not allowed.
Groups
When booking more than 4 rooms, different policies and additional supplements may apply.
Accepted payment methods
American ExpressVisaCartaSiCash

The fine print

Need-to-know information for guests at this property

Please note that parking spaces are limited and subject to availability.

In response to Coronavirus (COVID-19), additional safety and sanitation measures are in effect at this property.

License number: 058091-ALB-00313, IT058091A1GZ5MCI9I